Sprol

For decades, we have heard about the dangerous pesticides, herbicides and a myriad of industrial chemicals that have the potential of reaping havoc on our environment. Most of us take these dangerous chemicals, many which have caused lasting environmental damage throughout history, very seriously. And, rightly so. However, there are other synthetic chemicals that enter our waterways daily but are still not deemed as much of a danger to the planet. These drugs are “steroids.”

Photo credit: Hot Raw Sewage by Trey Ratcliff

Of course, steroids have long been in the spotlight as numerous professional athletes admit to using steroids as a shortcut to enhancing their performance and helping them achieve victory over their fellow athletes. The term “steroid,” however, actually encompasses a relatively large class of biological molecules.

These molecules include virtually anything the body makes from the parent molecule, cholesterol. Most happen to be hormones or intermediate chemicals in hormone synthesis and metabolism, or synthetic drugs that imitate hormones or interfere with natural hormone action.

Steroids include such chemicals as the anti-inflammatory hormone cortisol (hydrocortisone), which is typically added to medicated skin creams. Synthetic varieties of cortisol are also the active ingredients in organ transplant anti-rejection drugs and asthma inhalers.

Additionally, the primary sex hormones are also considered steroids. Estradiol, the main natural form of active estrogen, and progesterone dominate in women. For men, testosterone, the main natural form of active androgen, dominates. In fact, it is testosterone and other natural and synthetic varieties of androgens that are the main steroids used for muscle enhancement by athletes.

While it has long been known that these male forms of anabolic steroid drugs cause liver cancer, the news has not been spread about the environmental consequences of oral contraceptives (“the Pill”), levonorgestrel (“the morning-after pill”), and mifepristone, or RU-486, (“the abortion pill”). That fact is that all of these synthetic chemicals are also all steroids. These chemicals are actually the same sort of synthetic anabolic steroids that are illegal for professional athletes to take. The difference is that they are anabolic for female tissues, like breast tissue, rather than muscle.

In wasn’t until 2006 that the World Health Organization acknowledged that the estrogen-plus-progestin drugs, which include birth control pills and combination hormone replacement drugs, like Prem-Pro, do have the potential to cause cancers in the breast, cervix and liver.

And, here lies the connection between these synthetic drugs and the part they play as environmental pollutants. It is not common knowledge, but it is fact, that in order for contraceptive steroids to function effectively as pills, they must be non-biodegradable, at least by the human liver. The liver is the first stop for any substance absorbed through the digestive tract before it enters the body’s blood circulation.

In fact, it is one of the liver’s jobs to metabolize, or break down, all substances in order to detoxify them before they can adversely affect the rest of the body. Because of this, these drugs must interfere with the liver’s normal function. While this is true of many oral medications, how many prescription drugs are taken daily for decades by hundreds of millions of women worldwide?

Because of this massive use of synthetic contraceptives, there is a substantial percentage of the worldwide human population who excretes significant quantities of synthetic, carcinogenic and largely non-biodegradable female sex steroid drugs into the environment every day.

photo credit: elbisreverri

This situation is only complicated by the fact that out of all the steroid hormones that act within our bodies, the estrogens are by far the most potent. And, it is important to note that even the monthly highest level of estradiol in a non-pregnant woman’s bloodstream is measured in parts per trillion. Additionally, the most common form of estrogenic steroid drug found in many oral contraceptives, 17-alpha ethinyl estradiol (EE2), is even more potent than estradiol.

For over a decade now, EE2 has actually been showing up in waste water, groundwater and streams that are downstream from major metropolitan areas. There is mounting, creditable research and evidence that documents this contamination. This contamination is beginning to have significant affects on the reproductive function and is feminizing fish and other wildlife.

With this mounting contamination comes a worldwide effort to find ways to remove EE2 and other estrogenic contaminants from our water supplies. Put simply, the chemical inactivation of EE2 is quite simple. In effect, the same types of techniques used to purify our drinking water, such as ozone and ultraviolet light treatment, will work, however most see treating raw sewage by these methods as extremely impractical.

So, while there has been significant research in the area of synthetic contraceptive pollution, much of the research findings are not yet widely know. Even though the World Health Organization has acknowledged the carcinogenicity of synthetic contraceptive steroids, is still hardly mainstream knowledge.

The fact remains, however, that our health and the health of our environment, is being affected by the excreted amounts of these steroids. For years now, reports have also been growing from around the world that the massive amounts of synthetic birth control hormones being pumped into the water systems through sewage outflow is changing the sex of many types of fish.

Going back as far as 2002, the UK Environment Agency issued warnings that fish stocks in several British rivers were showing signs of gender ambiguity as a direct result of high levels of estrogen in the water. A survey of 1,500 fish at 50 river sites found more than a third of males also displayed female characteristics.

photo credit: Joseph Wu

Roughly two years ago, scientists at University of Colorado found that out of 123 fish caught in Boulder Creek, which is downstream from the Boulder sewage treatment plant, 101 were female, 12 were male and 10 had both male and female characteristics.

And, more recently, University of Pittsburgh research scientists investigated fish populations in the Allegheny River near storm sewer outflow pipes and discovered the same types of deformations. This is noteworthy as that region is dependent upon the Allegheny system for clean and safe drinking water.

Dr. Conrad Daniel Volz from the University of Pittsburgh Center for Environmental Oncology even warned that this significant rise in steroid hormones in drinking water throughout the Pittsburgh area is a real threat to human health. Numerous studies have now shown a link between contraceptive estrogen and hormone problems and cancers, including testicular and breast cancers.

The Pittsburgh Post-Gazette reported that other study results have also shown ambiguous gender in as much as 85 percent of the catfish caught on the Allegheny, Ohio and Monongahela rivers. In fact, chemicals extracted from 25 randomly sampled fish caused the growth of estrogen-sensitive breast cancer cells cultured in a laboratory, out of which 11 produced very aggressive cancers.

Of course, scientists and environmental groups alike are very careful to avoid making recommendations for restricting artificial contraceptives.

As we all know, most of us would not take kindly to the suggestion of restricting or banning hormonal contraceptives. In today’s modern world, it has become not just an issue of economic necessity, but also an issue of personal choice and freedom.

However, while estrogenic chemicals are affecting and altering the reproduction and gender of aquatic life, it should be natural to wonder what lasting and long-term affects these popular drugs are having on the future reproductive ability of humans.

It seems a cocktail of dangerous chemicals are leaking into our fresh water supply, and we all need to consider tougher safety margins and practices that will better protect the planet and all who live on it, both the wildlife and humans.